ZytoLight ® SPEC ABL1 Dual Color Break Apart Probe

The ZytoLight ® SPEC ABL1 Dual Color Break Apart Probe is designed to detect rearrangements involving the chromosomal region 9q34.12 harboring the ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase, a.k.a. ABL) gene. Chromosomal rearrangements involving ABL1 occur in various hematological malignancies leading to fusions of the ABL1 gene to different fusion partners. The translocation t(9;22)(q34.1;q11.2) results in BCR/ABL1 fusion and is observed in approx. 90% of patients with chronic myeloid leukemia (CML) and in approx. 25% of adults with acute lymphoblastic leukemia (ALL). The rearrangements are cytogenetically characterized by the presence of the Philadelphia (Ph) chromosome.