ZytoLight ® SPEC BCL2L1/CEN 20 Dual Color Probe

The ZytoLight ® SPEC BCL2L1/CEN 20 Dual Color Probe is designed for the detection of BCL2L1 gene amplifications. The BCL2L1 (BCL2-like 1, a.k.a. BCLX) gene is located in the chromosomal region 20q11.21 and encodes for an antiapoptotic protein that belongs to the BCL2 family. These genes are involved in a wide variety of cellular activities including lymphocyte development and hematopoiesis. BCL2L1 amplifications have been reported in several human cancers including lung, ovarian breast, melanoma, and hematologic malignancies.