ZytoLight ® SPEC BCL6 Dual Color Break Apart Probe

 The ZytoLight SPEC BCL6 Dual Color Break Apart Probe is designed for the detection of translocations involving the chromosomal region 3q27.3 harboring the BCL6 gene. Chromosomal rearrangements of the BCL6 gene region were found to occur in different types of non-Hodgkin lymphoma (NHL), including diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL).

DLBCL which are positive for both BCL6 and MYC rearrangements have been shown to have an extremely poor prognosis.