ZytoLight ® SPEC CCND1 Dual Color Break Apart Probe

 The ZytoLight ® SPEC CCND1 Dual Color Break Apart Probe is designed to detect translocations involving the chromosomal region 11q13.3 harboring the CCND1 gene. The CCND1 gene (cyclin D1, a.k.a. PRAD1) encodes a regulatory subunit of cyclin-dependent kinases. Translocations involving the chromosomal region t(11;14) (q13.3;q32.3) are considered

to be characteristic for mantle cell lymphomas (MCL) but have also been identified in other lymphoproliferative disorders (LPDs), such as B prolymphocytic leukemia, and, less frequently, in plasma cell myelomas, B-cell chronic lymphocytic leukemia, and in splenic lymphomas with villous lymphocytes (SLVL).