ZytoLight ® SPEC D13S319/13q34/CEN 12 Triple Color Probe

 The ZytoLight ® SPEC TP53/ATM Dual Color Probe is designed for the detection of deletions affecting the genes TP53 and ATM, and the ZytoLight ® SPEC D13S319/13q34/CEN 12 Triple Color Probe is designed for the detection of D13S319 deletions as well as for the enumeration of chromosome 12. CLL (chronic lymphocytic leukemia) is the most common form of leukemia in Western population. TP53 (tumor protein 53, a.k.a. p53) gene  deletions have been detected in patients with CLL, multiple myeloma (MM), and acute myeloid leukemia (AML). In CLL patients, allelic loss of the short arm of chromosome 17 is associated with treatment failure with alkylating agents and short survival times.