ZytoLight ® SPEC ERBB2/D17S122 Dual Color Probe

 The ZytoLight ® SPEC ERBB2/D17S122 Dual Color Probe is designed for the detection of ERBB2 gene amplification frequently observed in solid malignant neoplasms e.g. breast cancer samples. The ERBB2 gene (a.k.a. HER2 and NEU) is located in the chromosomal region 17q12 and encodes a 185-190 kDa transmembrane glycoprotein, p185, acting as a cellular growth factor receptor. The p185 protein belongs to the EGFR (epidermal growth factor receptor) subgroup of the RTK (receptor tyrosine kinase) superfamily also including ERBB1 (HER1), ERBB3 (HER3), and ERBB4 (HER4). Amplification of the proto-oncogene ERBB2, observed in approximately 20% of all breast cancer samples, has been correlated with a poor prognosis of the disease.