ZytoLight ® SPEC FGFR3 Break Apart/FGFR2/FGFR1 Quadruple Color Probe

The ZytoLight ® SPEC FGFR3 Break Apart/ FGFR2/FGFR1 Quadruple Color Probe is designed for the simultaneous detection of FGFR3 gene rearrangements, and of the FGFR2 and FGFR1 gene copy number status. Fibroblast growth-factor receptors (FGFRs) are involved in the regulation of organ development, cell proliferation and migration, and other processes. FGFR-activating genetic changes, including amplifications and translocations, were shown to be associated with the development and progression of tumors. Rearrangements affecting the FGFR3 gene are frequently found in carcinomas of various types, including multiple myeloma (MM), bladder cancer, glioblastoma, and lung squamous cell carcinoma. FGFR2 amplifications were found to occur in some gastric and breast tumors. FGFR1 is amplified in 21% of lung adenocarcinomas but also in other solid tumors, including oral squamous cell carcinoma, breast, ovarian, and bladder cancer. Various types of FGFR inhibitors are available, some of which have entered anti-tumor clinical trials and have shown promising clinical effects and application prospects. Thus, detection of FGFR aberrations may help in selecting patients eligible for an FGFR-targeted therapy.