ZytoLight ® SPEC FOXO1-PAX3 Dual Color Single Fusion Probe

The ZytoLight ® SPEC FOXO1/PAX3 Dual Color Single Fusion Probe and SPEC FOXO1/PAX7 Dual Color Single Fusion Probe are designed to detect translocations t(2;13)(q36;q14.1) and t(1;13)(p36.1;q14.1) in alveolar rhabdomyosarcomas. Among solid tumors of the childhood, rhabdomyosarcoma is the most common soft tissue sarcoma. Rhabdomyosarcomas are classified in two main categories: embryonal and alveolar rhabdomyosarcoma. The alveolar histology is associated with a poorer prognosis. Alveolar rhabdomyosarcoma is characterized by two tumor-specific translocations, i.e., t(2;13)(q36;q14.1) and t(1;13) (p36.1;q14.1) which are detectable in most cases of alveolar rhabdomyosarcomas. The translocations and their fusion genes represent highly specific genetic markers useful in the diagnosis of alveolar rhabdomyosarcomas. Correlations between the type of translocation and clinical features as e.g. longer disease-free survival have been identified.