ZytoLight ® SPEC NTRK1 Dual Color Break Apart Probe

The ZytoLight ® SPEC NTRK1 Dual Color Break Apart Probe is designed to detect translocations involving the chromosomal region 1q23.1 harboring the NTRK1 (neurotrophic tyrosine kinase receptor type 1, a.k.a. TRKA or TRK) gene. NTRK1 encodes a tyrosine kinase (TK) receptor for the nerve growth factor (NGF). The NTRK1 gene was found to be rearranged in about 12% of papillary thyroid carcinoma (PTC) cases. PTC accounts for about 80% of all thyroid cancers.