Cluster of differentiation 14 (CD14) is a cell surface glycoprotein expressed on monocytes and macrophages. It cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). It is also involved in NF-kappa-B activation, cytokine secretion, the inflammatory response, and up-regulation of cell surface molecules.
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