The ZytoLight ® SPEC BCL2L2/14q32 Dual Color Probe is designed for the detection of BCL2L2 gene amplifications. The BCL2L2 (BCL2-like 2, a.k.a. BCL-W) gene is located in the chromosomal region 14q11.2 and encodes for an anti-apoptotic protein that belongs to the BCL2 family. These genes are involved in a wide variety of cellular activities including lymphocyte development and hematopoiesis. BCL2L2 amplifications have been reported in several human cancers including lung, ovarian, breast, and hematologic malignancies. BCL2L2 amplifications are found in many tumor cell lines with resistance to chemotherapeutic agents. Targeting the BCL2 family proteins with small non-peptidic compounds, so called BH3-mimetics, is currently investigated in clinical trials. Hence, the identification of BCL2L2 amplifications by Fluorescence in situ Hybridization and the inhibition of BCL2L2 signaling may be of therapeutic significance in various types of tumors.
1 ZytoLight ® SPEC BCL2L2-14q32 Dual Color Probe
2 ZytoLight ® SPEC BCL2L2-14q32 Dual Color Probe