The ZytoLight ® SPEC BRAF/CEN 7 Dual Color Probe is designed for the detection of amplifications involving the chromosomal region 7q34 harboring the BRAF gene (B-Raf proto-oncogene, serine/ threonine kinase). The BRAF gene encodes a protein-serine/threonine kinase that participates in the MAPK cascade, which regulates a large variety of cell processes. Activating mutations in BRAF are found in many tumor types, including malignant melanoma, thyroid, colorectal, and ovarian carcinomas, lung adenocarcinoma, as well as in some sarcomas and gliomas. These mutations lead to constitutive activation of BRAF thereby promoting tumorigenesis.
