ZytoLight ® SPEC CCND1 Break Apart/2q11/CEN 6 Quadruple Color Probe

 The SPEC CCND1 Break Apart/2q11/ CEN 6 Quadruple Color Probe is a mixture of a green and a red fluorochrome direct labeled probe hybridizing proximal and distal to the breakpoint on 11q13.3, respectively, a gold fluorochrome direct labeled CEN 6 probe specific for the alpha satellite centromeric region of chromosome 6 (D6Z1), and a blue fluorochrome direct labeled SPEC 2q11 probe. The SPEC 2q11 probe is specific for the AFF3 (AF4/FMR2 family, member 3) gene region in 2q11.2. Due to cross-hybridizations of chromosome 2 alpha satellites to other centromeric regions, probes specific for 2q11 are frequently used for chromosome 2 copy number detection.