The ZytoLight SPEC IRF4,DUSP22 Dual Color Break Apart Probe is designed to detect translocations involving the DUSP22 and IRF4 genes. Rearrangements of the IRF4/DUSP22 chromosomal region have been detected in various B-cell and T-cell lymphomas.
Large B-cell lymphoma (LBCL) with IRF4 rearrangement is considered a distinct new provisional entity. Most cases have IG/IRF4 fusions and have a favorable prognosis. Moreover, IRF4 translocation has a high specificity for cutaneous cutaneous anaplastic large cell lymphoma (ALCL) supporting the clinical utility of FISH for IRF4 in the differential diagnosis of T-cell lymphoproliferative disorders.
