The ZytoLight ® SPEC EGFR/CEN 7 Dual Color Probe is designed for the detection of EGFR gene amplification frequently observed in solid neoplasms including non-small-cell lung cancer (NSCLC) and glioblastoma. The EGFR gene (a.k.a. ERBB1 and HER1) is located in the chromosomal region 7p11.2 and encodes a transmembrane glycoprotein acting as a cellular growth factor receptor. The protein belongs to the EGFR (epidermal growth factor receptor) subgroup of the RTK (receptor tyrosine kinase) superfamily also including ERBB2 (ERBB2), ERBB3 (HER3), and ERBB4 (HER4).
