The ZytoLight SPEC ERBB2/CEN 17 (HER2 / CEN 17 Z-2020 -20 - or CerbB2) Dual Color Probe is designed for the detection of ERBB2 (a.k.a HER2) gene amplification frequently observed in solid malignant neoplasms e.g. breast cancer samples.
Amplification of the proto-oncogene ERBB2, observed in approximately 20% of all breast cancer samples, has been correlated with a poor prognosis of the disease. In addition, detection of ERBB2 amplification by FISH may help in selecting patients eligible for ERBB2-targeted therapy.
