The ZytoLight ® SPEC FGFR2 Dual Color Break Apart Probe is designed to detect rearrangements involving the chromosomal region 10q26.13 harboring the FGFR2 (fibroblast growth factor receptor 2, a.k.a. BEK) gene. Translocations and inversions affecting FGFR2 have been detected in several solid tumors, including e.g. breast cancer, lung cancer, and the intrahepatic subtype of cholangiocarcinoma. Several partner genes have been described to be fused to FGFR2 after rearrangement. The resulting fusion genes are predicted to encode chimeric proteins carrying the kinase domain of FGFR2. Most of the currently known FGFR2 fusion products are likely to exhibit oligomerization capability resulting in kinase activation.
