ZytoLight ® SPEC FGFR3/4p11 Dual Color Probe

The ZytoLight ® SPEC FGFR3/4p11 Dual Color Probe is designed for the detection of FGFR3 gene amplifications. The FGFR3 (fibroblast growth factor receptor 3) gene is located in the chromosomal region 4p16.3 and encodes a receptor tyrosine kinase. FGFR family members differ from one another in their ligand affinities and tissue distribution. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The FGFR3 protein binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Activating mutations are associated with multiple myeloma, cervical carcinoma, and carcinoma of the bladder. Additionally, it was found that copy number gains at 4p16.3 occurred significantly more frequently in recurred/metastasized salivary gland adenoid cystic carcinoma (ACC) compared with indolent ACC.