The ZytoLight SPEC USP6 Dual Color Break Apart Probe is designed to detect translocations involving the USP6 gene. Translocations affecting USP6 have been initially found in primary aneurysmal bone cysts (ABC), a benign, but locally aggressive bone lesion. More recently, nodular fasciitis (NF), another mesenchymal lesion, has been tested positive for USP6 rearrangements. For both lesions it is assumed that the detection of USP6 rearrangements by FISH represents a valuable diagnostic tool.
