Description:
Anti-CD10 (CALLA), CE certified (IVD)
Alias names:
NEP, encephalokinase, neprilysin
Immunogen:
Recombinant protein encoding external domain of human CD10.
Substrate/Buffer:
Mouse monoclonal antibody from cell culture supernatant in PBS, pH 7.4 with carrier protein.
Technical Specifications:
Pre-treatment: Heat Induced Epitope Retrieval in Citrate Buffer pH 6.0
Control tissue: Tonsil, lymph nodes, kidney
CD10 (CALLA, Common Acute Lymphoblastic Leukemia Antigen) is an integral Type II-membrane protein with a molecular weight of 100 kDa. CD10 was identified as a human membrane associated neutral metalloendopeptidase. Synonyms are NEP, encephalokinase or neprilysin. CD10 is present on precursor B-cells, a subset of precursor T-cells, mature granulocytes, approximately 75 % of B-ALL, a subsetof T-ALL/T-LBL, and on all ALL-subtypes. Burkitt’s lymphomas and myelomas stain positive for CD10, as well as some diffuse large-cell B-cell lymphomas and most follicular lymphomas. Few tumours of epithelial origin like carcinomas of the kidney, bladder, prostate, uterus and liver stain also positive. MALT lymphomas and mantel cell lymphomas are negative for CD10. CD10 is a frequently utilised marker for differential diagnosis of lymphomas but is also used for discrimination of e.g. hepatocellular carcinomas vs. liver metastases of other origins.
